HEART DISEASE SYMPTOMS Heart disease can obviously in a Different type of symptoms: Chest pain or discomfort: This is the most common symptom of heart disease. The pain can feel like a pressure, squeezing, Perfection, or burning feeling in the chest. It may also be accompanied by shortness of breath, sweating, or nausea. Shortness of breath: Feeling breathless or having difficulty catching your breath can be a sign of heart disease. This can occur during physical activity or at rest. Fatigue: Feeling tired or exhausted, especially after exertion, can be a symptom of heart disease. ...